HORDB

General Information

ID: hor002467
Uniprot ID: NA
Protein name: histidine-rich basic peptide
Gene name: NA
Organism: Aplysia californica
Family: NA
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: EVAQMHVWRAVNHDRNHGTGSGRHGRFLIRNRYRYGGGHLSDA
Length: 43
Propeptide: NA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Excites Aplysia heart and enhances gut motility
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002467_AF2.pdb

hor002467_ESM.pdb

Physical Information

Mass:	569177	Formula:	C211H323N79O59S
Absent amino acids:	CKP	Common amino acids:	GR
pI:	11.74	Basic residues:	12
Polar residues:	15	Hydrophobic residues:	11
Hydrophobicity:	-106.51	Boman Index:	-14055
Half-Life:	1 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	54.42
Instability Index:	1910.7	Extinction Coefficient cystines:	8480
Absorbance 280nm:	201.9

Literature

PubMed ID: 2573895
Title: Aplysia Californica Neurons R3-R14: Primary Structure of the Myoactive Histidine-Rich Basic Peptide and Peptide I